| 摘要 |
Compounds of general formula (1), or a pharmaceutically acceptable salt thereof: wherein R<1> is selected from H, lower alkyl, R<4>-CO, R<4>-O2CCH2, R<5>-OCO and R<5>-SO2; R<2> is selected from lower alkyl, cycloalkyl optionally substituted with an alkyl or alkyloxy group, (C5-C12)cycloalkylalkyl optionally substituted with an alkyl or alkyloxy group, aralkyl optionally substituted with up to three groups chosen from F, CI, Br, I, OH, lower alkyl, O-(lower alkyl), O-benzyl, NH2, NO2, NH-acyl, CN and CF3, and aralkyloxymethyl optionally substituted with up to three groups chosen from F, CI, Br, OH, lower alkyl and O-(lower alkyl); or R<1> and R<2> together are an o-xylylene group optionally substituted on the aromatic ring with a group selected from F, CI, Br, OH, lower alkyl and O-(lower alkyl); R<3> is selected from H, OH and O-lower alkyl; R<4> is selected from H, lower alkyl and phenyl; and R<5> is selected from lower alkyl, phenyl and benzyl. The compounds are useful as pharmaceutical compositions. |
