Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists

摘要

This invention provides a compound of the formula: and its pharmaceutically acceptable salts, wherein R<1 >is C1-C6 alkyl; R<2 >is hydrogen, C1-C6 alkyl, halo C1-C6 alkyl or phenyl; R<3 >is hydrogen or halo; R<4 >and R<5 >are independently hydrogen, C1-C6 alkyl or halo C1-C6 alkyl; and n is one, two or three. These compounds are useful as analgesics or anti-inflammatory agents, or in the treatment of cardiovascular diseases, allergic disorders, angiogenesis, CNS disorders, emesis, gastrointestinal disorders, sunburn, urinary incontinence, or diseases, disorders or adverse conditions caused by Helicobacter pylori, or the like, in a mammalian subject, especially humans. Intermediates for preparation of the compounds of Formula (I) are also disclosed.