COMPOSITIONS AND METHODS FOR TREATING ATHEROSCLEROSIS

摘要

The invention provides a nucleic acid having a nucleotide sequence encoding an inhibitor of a proatherogenic molecule operationally linked to a macrophage-specific expression element. The invention also provides a recombinant macrophage expressing a nucleic acid encoding an inhibitor of a pro-atherogenic molecule. The invention further provides a method for inhibiting or reducing atherosclerosis including administering to an individual a population of recombinant cells expressing a nucleic acid encoding an inhibitor of a pro-atherogenic molecule. Additionally, the invention provides a method for inhibiting or reducing atherosclerosis including administering to an individual a nucleic acid encoding an inhibitor of a pro-atherogenic molecule, the inhibitor of a pro-atherogenic molecule operationally linked to a macrophage-specific expression element.