ANTAGONISTS OF MCP-1 FUNCTION AND METHODS OF USE THEREOF

摘要

The present invention relates to chemical compounds of Formula (I) or (II) (wherein Y, Z and R<1> - R<6> are defined herein), pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.