发明名称 |
METHOD OF FINGERPRINTING TISSUE SAMPLES |
摘要 |
The present invention is directed to methods of determining a copy number of nucleic acids in a biological specimen. More specifically, the invention provides a method for determining an absolute copy number of a transcript or a plurality of transcripts of interest in a biological specimen the size of which is determined using an external control. The invention further provides a method for diagnosis and prognosis of diseases associated with changes in a transcript copy number by measuring an absolute copy number of the transcript. The invention also provides a kit for measuring absolute copy number of a transcript or a plurality of transcripts. The invention further provides a method of creating a quantitative "fingerprint" of a disease-related gene expression pattern for screening to identify susceptibility to a disease, and disease diagnostic and prognostic purposes. |
申请公布号 |
WO03091410(A2) |
申请公布日期 |
2003.11.06 |
申请号 |
WO2003US12964 |
申请日期 |
2003.04.25 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;SMITH, LOIS;SHIH JAMINET, SHU-CHING |
发明人 |
SMITH, LOIS;SHIH JAMINET, SHU-CHING |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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