| 摘要 |
Compounds of formula Iwherein R is carboxy, esterified carboxy or amidated carboxy;R1 and R3 are independently lower alkyl, (hydroxy, lower alkoxy, amino, acylamino, mono- or di-lower alkylamino or mercapto)-lower alkyl, lower alkyl-(thio, sulfinyl or sulfonyl)-lower alkyl, cycloalkyl, aryl, biaryl, (cycloalkyl, aryl or biaryl)-lower alkyl, or (carboxy, esterified carboxy or amidated carboxy)-lower alkyl;R2 is hydrogen, lower alkyl, cycloalkyl, aryl, biaryl, arylaminocarbonyl, or aryl-(oxy, thio or amino);n is 1 or 2;Y is lower-alkylene or lower alkenylene;and pharmaceutically acceptable salts thereof; which are useful as LFA-1 antagonists.
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