发明名称 |
Milling process for the production of finely milled medicinal substances |
摘要 |
The invention is an improved method of generating fine medicament powders suitable for inhalation. A fluid energy mill is used with conventional milling fluids such as air or nitrogen. The milling fluid is treated to have a controlled relative humidity of between 30% and 70%. This produces a fine medicament powder with a median particle size below 10 micrometer but with little or no amorphous content generated during milling. Scale formation in the mill chamber is also greatly reduced.
|
申请公布号 |
US6641063(B2) |
申请公布日期 |
2003.11.04 |
申请号 |
US20010873161 |
申请日期 |
2001.06.01 |
申请人 |
AVENTIS PHARMA LIMITED |
发明人 |
VEMURI NARASIMHA M.;BROWN ANDREW B.;AUTHELIN JEAN-RENE;HOSEK PATRIK |
分类号 |
A61K9/12;A61K9/00;A61K9/14;A61K31/137;A61K31/573;A61P11/06;A61P29/00;B02C19/06;B02C19/16;B02C23/06;(IPC1-7):B02C19/06;B02C19/12 |
主分类号 |
A61K9/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|