摘要 |
Compounds of the formulawherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C;Y is of the formulaor a stereoisomer thereof,wherein R<1 >is substituted or unsubstituted alkyl;each R<2 >is independently H, hydroxy, alkoxy (1-6C) or lower alkyl (1-4C);R<3 >is H, hydroxy, or alkoxy (1-6C); orY is of the formulawherein each n is 1,Z is N,K comprises a substituted or unsubstituted aromatic carbocyclic or heterocyclic ring system which may optionally be spaced from the linkage position shown in formula (7) by a linker of 1-2C, or in formula (7), Z may be spaced from the carbon bonded to X by =CR<6>- wherein R<6 >is H or linear, branded or cyclic alkyl (1-6C),R<5 >is H or linear, branched or cyclic alkyl, andR' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C,promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.Also disclosed is a method to identify additional compounds which are inhibitors of enzymes in the isoprenoid scheme especially of HMG-CoA reductase which results in prenylation of proteins and in the synthesis of steroids or of inhibitors of their production which are useful in treating bone disorders.
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