| 摘要 |
Production of a covalent conjugate (I) of hydroxyethyl starch (HES) and an active agent (A), comprises reacting HES and (A) in a reaction medium. Production of a covalent conjugate (I) of hydroxyethyl starch (HES) and an active agent (A), comprises reacting HES and (A) in a reaction medium, the reaction medium consists of water or a water-organic solvent mixture containing at least 10 weight. % water. An independent claim is included for (I).
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