Water soluble prodrugs of hindered alcohols or phenols

摘要

A compound of formula (I) or (IV) or pharmaceutically acceptable salts thereof wherein: R-O- is a is a residue of a phenol containing pharmaceutical compound excluding taxol and taxol derivatives; R1 and R2 independently are hydrogen, an alkali metal ion, a protonated amine or a protonated amino acid; Y is a phosphono protecting group; n is 1 or 2 and m is at least 1.