Benzo-1,3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists

摘要

Compounds a) (2R, 3R, 4S)-2-(3-Fluoro-4methoxyphenyl)-4-(1.3- benzodioxol-5-yl)-1-(2-(N-propyl-N- pentanesulfonylamino)ethyl)-pyrrolidine-3-carboxylic acid b) trans, trans-2-(2,2-Dimethylpentyl)-4-(7-methoxy-1,3- benzodioxol-5-yl)-1-(N,N-dibutylaminocarbonylmethyl)- pyyrolidine-3-carboxylic acid c) trans, trans-2-(4-Methoxyphenyl)-4-(1,3-benzodioxol-5- yl)-1-[(N-butyl-N-(4- dimethylaminobutyl)amino)carbonylmethyl]-pyyrolidine-3- carboxylic acid The uses of the compounds may include antagonsing endothelin in a mammal, treating - hypertension, congestive heart failure, restenosis following arterial injury, cerebral ischemia, myocardial ischemia, atherosclerosis, angina, cerebral vasospasm, a LPL-related lipoprotein disorder, Raynaud's disease, nociception and cancer.