发明名称 |
Production of mycobacterial polypeptides by lactic acid bacteria |
摘要 |
A method of producing, in a recombinant lactic acid bacterium such as Lactococcus lactis, a bioreactive polypeptide derived from mycobacteria belonging to the M. tuberculosis complex Mycobacterium tuberculosis, Mycobacterium africanum and Mycobacterium bovis or any other mycobacterial species. The lactic acid bacterially produced polypeptide is in the form of monomer or polymers of one or more polypeptide and it is useful as a diagnostic agent in delayed type hypersensitivity (DTH) skin tests in animals and humans and in vaccines. A bioreactive ESAT-6 homodimer polypeptide is described.
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申请公布号 |
NZ507278(A) |
申请公布日期 |
2003.10.31 |
申请号 |
NZ19990507278 |
申请日期 |
1999.03.05 |
申请人 |
STATENS SERUM INSTITUT |
发明人 |
JENSEN, CARSTEN LOVSTRUP;FOLKERSEN, JORGEN |
分类号 |
G01N33/569;A61K39/00;A61K39/04;A61K39/39;C07K14/35;C07K19/00;C12N15/09;C12N15/31;C12P21/02;(IPC1-7):IPC7:C12;IPC7:;G01N3;A61P31/06 |
主分类号 |
G01N33/569 |
代理机构 |
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地址 |
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