Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them

摘要

Described are spiroimidazolidine derivatives of the formula I in which E, V, W, X, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which are suitable, for example, for the therapy and prophylaxis of inflammatory disorders such as arthritis, rheumatoid arthritis, polyarthritis, inflammatory bowel disease, systemic lupus erythematosus, multiple sclerosis or inflammatory disorders of the central nervous system which comprises administering to a subject in need thereof an effective amount of a composition comprising one or more compounds of the formula I. The compounds of the formula I are also inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4 belonging to the integrins group. They are generally suitable for the therapy and prophylaxis of illnesses which are caused by an undesired extent of leukocyte adhesion and/or leukocyte migration or are associated therewith or in which cell-cell or cell- matrix interactions which are based on interactions of VLA- 4 receptors with their ligands play a part. Also described are processes for the preparation of the compounds of the formula I and pharmaceutical preparations which contain compounds of the formula I.