| 摘要 |
The indole or carbazole derivatives of formula I are used in the manufacture of medicament for the treatment of chronic lymphocytic leukemia (CLL), B-cell lymphoma or lymphoma wherein: R1 is hydrogen, lower alkyl, lower alkeny, lower alkynyl, alkoxyloweralkyl, lower cycloalkyl, phenyl, benzyl and 2- thienyl; R2 and R3 are the same or different selected from hydrogen and lower alkyl; R4 and R5 are the same or different selected from hydrogen, lower alkyl, -NH2, -NHCHO, -NHCONH2, =NW, oxo, -OH and OCH3, wherein W is hydroxy, alkoxy, aryloxy, carboxyalkyloxy, arylamino or alkylsulfonylamino R6 is selected from hydrogen, lower alkyl, lower alkenyl, lower alkynyl, trifluromethyl, hydroxy, lower alkoxy, trifluroloweralkoxy, benzyloxy, araloxy, lower alkanoyloxy, acyl, amino, nitro, cyano, alkylimido, halo, mercapto, loweralkylthio, alkylsulfinyl, alkylsulfonyl, akylsulfonamido and sulfamoyl; R7 is selected hydrogen, lower alkyl and lower alkenyl; X is selected form carbon, oxy and thio; Y is selected from carbonyl, and formulas (a)-(c); R8, R9, R10, R11, R12 and R13 are hydrogen or lower alkyl and Z is selected form hydroxy, lower alkoxy, amino, lower alkylamino, di(lower)alkylamino and phenylamino; Or pharmaceutically acceptable salt thereof.
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