| 摘要 |
Described is a compound of the formula (I), where: Z2 is -O2S-, -O-, -N(R107)-, -OS-, or-S-; w is 0, 1, 2, or 3; R23 and R24 are the same or different and can be H or F; and R1 is H; NH2; NHalkyl; N(alkyl)2; a group of formula (II); alkyl; Oalkyl; Salkyl; alkyl substituted with 1-3 F, 1-2 Cl, CN, or -COOalkyl, or cycloalkyl, wherein in each occurrence the alkyl group may be straight or branched; and R107 is R102O-C(R110)(R111)-C(O)-, R103O-C(O)-, R108-C(O)-, R109-SO2-, NC-CH2-, FCHCH2-, or R150R151NSO2-; wherein R102 is H, CH3-, phenyl-CH2-, or CH3C(O); each of R110 and R111 is selected from H or CH3; R103 is alkyl or phenyl; R108 is H, alkyl, aryl(CH2)0-5, CNCH2-, ClCH2-, Cl2HC-, FH2C-, F2HC- , or cycloalkyl; R150 and R151 are the same or different and are selected from H, alkyl, or R150 and R151 taken together with the nitrogen to which each is attached forms a monocyclic heterocyclic ring having from 3 to 6 carbon atoms; and R109 is alkyl, -CH2Cl, -CH2CH=CH2, aryl or -CH2CN.
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