The use of certain affinity NMDA antagonists as antidepressants

摘要

Described is the use of a low affinity NMDA antagonist of the formula (I) in the manufacture of a medicament for the treatment or prophylaxis of depression. In the compound of formula (I): R1 is pyridyl, phenyl or 4 fluorophenyl; R2 is phenyl or 4 flurophenyl; R3 is hydrogen, C1-6alkyl or methoxycarbonyl; R4 is hydrogen or methyl; and R5 is hydrogen or COCH2NH2