| 摘要 |
The invention relates to polypeptides different from the human interleukin, having at least one of the following properties: induce the inhibition of spontaneous IL-8 production by the human monocytes, induce the inhibition of production of IL-8 which induces IL-1 beta by the human peripheral blood mononuclear cells, induce the production of interleukin-1 receptor antagonist protein by human monocytes, induce the chemotactic migration of CD 8 + human T lymphocytes in vitro, desensitize the human CD 8 + T cells in vitro, desensitize the human CD 8 + T cells, resulting in an unresponsiveness thereof to rhIL-10, suppress the chemotactic response of CD 4 + human T-lymphocytes to IL-8, suppress the chemotactic response of human monocytes to MCA F/MCP-1, do not inhibit class II MHC molecules with expression of human monocytes, in contrast to human IL-10, induce the production of IL-4 by culturing normal human CD 4 + T cells, reduce the TNF alpha production in humans mixed leukocyte reaction. The invention relates especially to non-peptides Ala-Tyr-Met-Thr-Met-Lys-Ile-Arg-Asn, to analogues and variants thereof.
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