发明名称 |
PROCESS FOR PRODUCING IMMUNOGLOBLIN PREPARATION |
摘要 |
A process for producing an immunogloblin preparation that includes heating of an immunogloblin solution and that is simplified and has reduced aggregates. In particular, the process comprises the step of heating an aqueous solution containing immunogloblin wherein the protein concentration is 3 (w/v)% or less in the presence of 10 (w/v)% or more of a stabilizer at a pH value of 5.2 ± 0.5 and at a conductivity of 0.01 to 1 mSi and the subsequent step of, at a pH value of 7 to 9 and a conductivity of 0.01 to 1 mSi, isoelectric focusing and/or anion exchanger treatment, optionally together with the step of filtration with the use of a porous membrane of 1 to 100 nm average pore diameter at a pH value adjusted to 6-7.
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申请公布号 |
WO03088999(A1) |
申请公布日期 |
2003.10.30 |
申请号 |
WO2003JP03306 |
申请日期 |
2003.03.19 |
申请人 |
MITSUBISHI PHARMA CORPORATION;ITAGAKI, YOSHIO;URIYU, KATSUHIRO |
发明人 |
ITAGAKI, YOSHIO;URIYU, KATSUHIRO |
分类号 |
A61K39/395;A61P31/00;C07K16/00;C07K16/06;(IPC1-7):A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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