摘要 |
Compounds of formula 1 are effective modulators of P13 kinase: wherein X is CR9, R10, 0, NR11 (where R9 and R1O are each independently H, lower alkyl, lower alkoxy, or halo, and R11 is H or lower alkyl); or single bond; R1 is H, lower alkyl, aryl, aralkyl; R2 is H, lower alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, lower alkoxy, amino, lower alkylamino, lower acylamino, arylamino, arylacyl-amino, heteroaryl-amino, heteroaryl-acyl amino, thio, lower alkylthio, arylthio, or aralkyl-thio, where aryl and heteroaryl are substituted with 0-3 substituents selected from the group consisting of halo, trihalomethyl, hydroxy, lower alkyl and lower alkoxy; R3, R4, R5, R6, R7 and R8 are each independently H, lower alkyl, lower alkoxy, or halo; or a pharmaceutically acceptable salt or ester thereof. |
申请人 |
ICONIX PHARMACEUTICALS, INC.;MELESE, TERI;PERKINS, EDWARD, L.;NGUYEN, ALLEN, T., Q.;SUN, DONGXU |
发明人 |
MELESE, TERI;PERKINS, EDWARD, L.;NGUYEN, ALLEN, T., Q.;SUN, DONGXU |