发明名称 Dihydrofolate reductase inhibitors
摘要 A compound of formula (I) or (II), wherein X is hydrogen, halogen, alkyl, aralkyl,aryloxy, arylalkoxy or alkoxy, Y is hydrogen, halogen, alkyl, aralkyl, aryloxy, arylalkoxy or alkoxy, or formula (a) wherein A and B are different and one of A and B is CH2 and the other is O, NH, or S or A and B are both CH2 or CH=, and R<a>, R<b>, and R<c >are the same or different and are hydrogen, halogen, alkyl, alkoxy, aryloxy, aralkyl or arylalkoxy. R<1 >is hydrogen, and R<2 >is hydrogen, C1-C6 alkyl or aryl which is unsubstituted or substituted by halogen, cyano, hydroxy, C1-C6 alkyl, which is unsubstituted or substituted by halogen, cyano, hydroxy, C1-C6 alkoxy, aralkyl, aryloxy or aryl, C1-C6 alkoxy, aralkyl, arylalkoxy, aryloxy or aryl, which is unsubstituted or substituted by halogen, cyano, hydroxy, C1-C6 alkyl or C1-C6 alkoxy; and pharmaceutically acceptable salts thereof; with the proviso that when R<2 >is phenyl and Y is hydrogen, X is not chlorine.
申请公布号 US2003203908(A1) 申请公布日期 2003.10.30
申请号 US20030182047 申请日期 2003.02.24
申请人 LOWE GORDON 发明人 LOWE GORDON
分类号 A61K31/155;A61K31/277;A61K31/53;A61P33/06;C07C279/26;C07D251/10;(IPC1-7):C07D251/48 主分类号 A61K31/155
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