METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR DETERMINING THE BIOLOGICAL EFFECT AND/OR ACTIVITY OF DRUGS, CHEMICAL SUBSTANCES AND/OR PHARMACEUTICAL COMPOSITIONS BASED ON THEIR EFFECT ON THE METHYLATION STATUS OF THE DNA

摘要

This invention is related to methods, systems and computer program products for determining the biological effect and/or activity of drugs, chemical substances and/or pharmaceutical compositions using their effect on DNA-methylation as a marker for their biological effect(s). The invention is further related to the use of the inventive methods, systems and computer program products in obtaining new biologically active compounds which can be used as so-called "lead" compounds for new and effective medicaments and treatment strategies of, in particular, human diseases.