| 摘要 |
The present invention relates to compounds that alter GPCR internalization and new methods for their identification. Compounds of this invention include modified phosphoinositide 3-kinase (PI3K), modified HEAT domain, modified -adrenergic receptor kinase 1 ( ARK1), as well as other peptides or small molecules that alter GPCR internalization. The present invention also includes the use of such compounds to treat GPCR-related diseases, such as cardiovascular disease, heart failure, asthma, nephrogenic diabetes insipidus, or hypertension. |
| 申请人 |
DUKE UNIVERSITY;ROCKMAN, HOWARD, A.;NAGA PRASAD, SATHYAMANGLA, V.;LAPORTE, STEPHANE, A.;BARAK, LARRY, S.;CARON, MARC, G. |
发明人 |
ROCKMAN, HOWARD, A.;NAGA PRASAD, SATHYAMANGLA, V.;LAPORTE, STEPHANE, A.;BARAK, LARRY, S.;CARON, MARC, G. |
