MUTANT NDP KINASES FOR ANTIVIRAL NUCLEOTIDE ANALOG ACTIVATION AND THERAPEUTIC USES THEREOF

摘要

A polypeptide having a nucleoside or nucleotide kinase activity, which comprises a wild-type nucleoside or nucleotide kinase mutated at at least on e amino acid position within the active site of nucleoside or nucleotide kinas e to increase kinase catalytic activity towards a given nucleotide or nucleoside analog compared to the wild-type nucleoside or nucleotide kinase. A polynucleotide coding for said polypeptide. Methods, including therapeutic ones, using said polypeptide and polynucleotide.