NEW SOLID DOSE FORM OF NANOPARTICULATE NAPROXEN

摘要

Described are solid dose nanoparticulate naproxen formulations having high rates of dissolution. The solid dose nanoparticulate naproxen formulations c an comprise an alkali compound, which functions to increase the dissolution rat e of the naproxen following administration. Alternatively, the solid dose nanoparticulate naproxen formulation can comprise an alkali compound and an acidic compound, which can react together to form carbon dioxide. The formed carbon dioxide can also aid in increasing the dissolution rate of the naprox en following administration. Also described are solid dose nanoparticulate naproxen formulations having decreased concentration of a binder/disintegran t agent. Such compositions also provide an increased rate of dissolution of naproxen following administration.