METHOD FOR EXAMINING PRIMARY CAUSE OF THROMBOGENESIS TENDENCY

摘要

PROBLEM TO BE SOLVED: To provide a method for examining a primary cause of thrombogenesis tendency, and to provide a method for screening a compound useful for treating the thrombogenesis tendency.

SOLUTION: The method for examining the primary cause of the thrombogenesis tendency comprises a step for detecting polymorphism of an ADAMTS13 gene which causes reduction of activities of VWF nicking enzyme. The examining method enables the examination of the primary cause or the like of thrombotic thrombocytopenic purpura. The thrombotic thrombocytopenic purpura is an important disease as a side effect caused by administration of an anti-platelet agent preparation. The examination of the primary cause contributes to the improvement of safety o the anti-platelet agent preparation.

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