PROCESS FOR THE PREPARATION OF BASIC ANTIBIOTIC-INORGANIC ACID ADDITION SALTS AND INTERMEDIATE OXALATES

摘要

The present invention provides: an industrially-excellent and novel process for producing a basic antibiotic.inorganic acid salt, for example, an excellent production process for producing a hydrochloride thereof industrially, that is, a production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: (wherein the ring A means the basic antibiotic; R<10> means a protected functional group used in organic synthesis; Ak-E means the alkali earth metal; and B means the inorganic acid, respectively); a novel oxalate useful as a production intermediate for producing an antibiotic.hydrochloride industrially, that is, an oxalate (II-I) of a carbapenem compound represented by the following formula: (wherein the ring A represents a 3- to 7-membered ring having at least one nitrogen atom, and the ring A may be substituted with other than R<6>; R<1> represents hydrogen or methyl group; R<2> and R<5> are the same as or different form each other and each represents hydrogen or a hydroxyl-protecting group; R<3> represents a carboxyl-protecting group; R<4> represents hydrogen, a lower alkyl group or an amino-protecting group; R<6> represents (1) hydrogen, (2) an optionally protected hydroxyl group, carbamoyl, formimidoyl, acetoimidoyl or a lower alkyl group which may be substituted with a substituent represented by the formula: (wherein R<7> and R<8> are the same as or different from each other and each represents hydrogen, a lower alkyl group or an amino-protecting group) or (3) an amino-protecting group or an imino-protecting group; and m is 0 or 1); and a process for producing its.