发明名称 DERIVATIVE OF 3-ARYL-2-HYDROXYPROPIONIC ACID, METHOD FOR ITS PREPARING (VARIANTS), PHARMACEUTICAL PREPARATION, METHOD FOR TREATMENT AND INTERMEDIATE COMPOUND
摘要 FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivative of 3-aryl-2-hydroxypropionic acid, namely, to (S)-2-ethoxy-3-4-[2-(4-methanesulfonyloxyphenyl)ethoxy] phenyl-propionic acid of the formula (I) . Invention describes methods for preparing compound, intermediate substance used in synthesis, pharmaceutical preparation based on compound of the formula (I). Invention relates also to pharmaceutically acceptable salts, crystalline forms and solvates of compound of the formula (I). Compound is adapted for prophylaxis and/or treatment of clinical states associated with reduced sensitivity to insulin and associated with the latter metabolic disorders. EFFECT: improved preparing method, valuable medicinal properties of compound. 18 cl, 2 ex
申请公布号 RU2214999(C2) 申请公布日期 2003.10.27
申请号 RU20000130189 申请日期 1999.05.31
申请人 发明人
分类号 A61P3/06;A61K31/19;A61K31/192;A61K31/216;A61K31/255;A61P3/04;A61P3/08;A61P3/10;A61P9/10;A61P9/12;A61P43/00;C07C69/734;C07C217/76;C07C233/25;C07C233/29;C07C233/75;C07C235/42;C07C255/54;C07C271/28;C07C271/38;C07C271/44;C07C271/58;C07C275/34;C07C303/26;C07C309/65;C07C309/66;C07C309/68;C07C309/73;C07C311/08;C07C311/13;C07C311/16;C07C317/22;C07C317/28;C07C323/19;C07C323/44;C07C323/56;C07C335/18;C07D263/04;(IPC1-7):C07C309/68 主分类号 A61P3/06
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