ANTIGENIC PROFILING OF NEOPLASTIC CELLS, ONCOGENIC THERAPY UTILIZING FUNCTIONAL ANTIBODIES THERETO AND CYTOTOXIC IMMUNE COMPLEXES FORMED THEREBY

摘要

The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening and characterizing the target antigen thereof. The invention further relates to the process by which the antibodies are made and to their methods of use. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and their metastases. The anti-cancer antibodies can be combined with a variety of anti-neoplastic agents, e.g. Cisplatin, to derive a synergistic effect with regard to reduction in tumour growth kinetics and metastasis.