发明名称 |
Treatment of ulcerative colitis with tropomyosin isoforms and monoclonal antibodies to tropomyosin isoforms |
摘要 |
This invention pertains to a method for treating ulcerative colitis. Specifically, the method comprises orally or rectally administering to a human having ulcerative colitis a therapeutically effective amount of an antibody which binds to a tropomyosin isoform associated with ulcerative colitis. In another embodiment, the invention pertains to a method for treating ulcerative colitis in a human which comprises the steps of (a) obtaining from a human a colon epithelial cell extract containing a tropomyosin isoform associated with ulcerative colitis; (b) purifying the tropomyosin isoform until the tropomyosin isoform is substantially homogeneous; (c) developing an antibody which binds to the tropomyosin isoform; and (d) orally or rectally administering to a human having ulcerative colitis a therapeutically effective amount of the antibody to bind to the tropomyosin isoform associated with ulcerative colitis. In yet another embodiment, the invention pertains to a method for treating ulcerative colitis in a human which comprises orally administering to the human a therapeutically effective amount of a tropomyosin isoform associated with ulcerative colitis.
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申请公布号 |
US2003198635(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
US20030427196 |
申请日期 |
2003.05.01 |
申请人 |
UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY |
发明人 |
DAS KIRON M. |
分类号 |
C12N15/09;A61K38/00;A61K38/17;A61K39/395;A61P1/04;A61P43/00;C07K14/47;C07K16/18;C12P21/08;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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