发明名称 |
C-JUN PHOSPHORYLATION INHIBITORS |
摘要 |
BMAL1, BPL1, KIAA1491 complete (SEQ ID NO:1) and KIAA0596CT (SEQ ID NO:2) having a function of interacting with c-Jun N-terminal kinase 3 are found ou t. Using them and peptides originating therein, drugs and medicinal composition s to be used in inhibiting the phosphorylation of c-Jun, inhibiting the functions (for example, transcription activation) of c-Jun, inhibiting apoptosis (for example, apoptosis in nerve cells) and preventing and/or treating neurodegenerative diseases (for example, polyglutamine disease and Alzheimer~s disease) and a method therefor are provided.
|
申请公布号 |
CA2480671(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
CA20032480671 |
申请日期 |
2003.03.31 |
申请人 |
CELESTAR LEXICO-SCIENCES, INC.;DAIICHI PHARMACEUTICAL CO., LTD. |
发明人 |
NAKAJIMA, HIROTO;WADA, NAOYA;DOI, HIROFUMI |
分类号 |
A61K38/17;A61P25/00;(IPC1-7):A61K45/00 |
主分类号 |
A61K38/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|