发明名称 |
Polynucleotide compositions |
摘要 |
Compositions for stabilizing polynucleic acids and increasing the ability of polynucleic acids to cross cell membranes and act in the interior of a cell. In one aspect, the invention provides a polynucleotide complex between a polynucleotide and certain polyether block copolymers. The polynucleotide complex can further include a polycationic polymer, as well as suitable targeting molecules and surfactants. The invention also provides a polynucleotide complex between a polynucleotide and a block copolymer comprising a polyether block and a polycation block.
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申请公布号 |
US2003198678(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
US20020164875 |
申请日期 |
2002.06.07 |
申请人 |
KABANOV ALEXANDER V.;ALAKOV VALERY Y.;VINOGRADOV SERGEY V. |
发明人 |
KABANOV ALEXANDER V.;ALAKOV VALERY Y.;VINOGRADOV SERGEY V. |
分类号 |
C12N15/09;A61K9/107;A61K9/51;A61K31/70;A61K31/74;A61K39/12;A61K39/21;A61K39/245;A61K47/48;A61K48/00;A61P31/12;A61P35/00;C08F290/00;C08F297/00;C08L51/00;C08L53/00;C08L71/02;C08L89/00;(IPC1-7):A61K48/00;C08G63/48;C08G63/91;A61K9/14 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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