摘要 |
Sulfonamide derivatives of formula (1) are described wherein X is an O or S atom; Y is an 0 or S atom; A is a group -S02NR<1>R<2>; m is zero or the integer 1; n is zero or the integer 1; provided that at least one but not both of m and n are the integer 1; R<3> is a hydrogen atom or an alkyl or cycloalkyl group; and the salts, solvates, hydrates, tautomers, isomers, N-oxides thereof. The compounds are potent inhibitors of IMPDH and are of use as immunosuppressants, anti-cancer agents, anti-inflammatory agents, antipsoriatic and anti-viral agents. |
申请人 |
CELLTECH R & D LIMITED;HAUGHAN, ALAN, FINDLAY;DYKE, HAZEL, JOAN;WILLIAMS, SOPHIE, CAROLINE;LOWE, CHRISTOPHER;DRAFFAN, ALISTAIR, GEORGE;OWEN, DAVID, ALAN |
发明人 |
HAUGHAN, ALAN, FINDLAY;DYKE, HAZEL, JOAN;WILLIAMS, SOPHIE, CAROLINE;LOWE, CHRISTOPHER;DRAFFAN, ALISTAIR, GEORGE;OWEN, DAVID, ALAN |