| 摘要 |
Trifluoroalkylureido cephalosporins of the formula <IMAGE> wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group <IMAGE> R1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R2 is hydrogen or lower alkyl; R3 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R4 is hydrogen or lower alkyl; R5 is lower alkyl; and X is hydrogen, lower alkanoyloxy, <IMAGE> or certain heterothio groups are disclosed. These compounds are useful as antibacterial agents.
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