POLYPEPTIDE OF A P53 PROTEIN-SPECIFIC MURINE Alpha/beta T-CELL RECEPTOR, NUCLEIC ACIDS CODING THEREFOR AND USE THEREOF

摘要

The invention relates to polypeptides of a murine alpha/beta T-cell receptor mediating a p53 protein-specific T-cell response or functional variants or parts thereof or nucleic acids coding therefor, functional variants or parts thereof. Said polypeptides enable p53 protein-expressing cells to be recognized by T-cells provided with these genes, cytokines can be released, and T-cell induced lysis and/or apoptosis of tumor or leukemia cells can be performed.