OPTICAL ISOMER SEPARATION PACKING FOR SIMULATED MOVING BED CHROMATOGRAPHY

摘要

A packing that is suitable for fractionation by simulated moving bed chromatography, ensuring high productivity. In particular, an optical isomer separation packing for simulated moving bed chromatography wherein a polysaccharide derivative is borne on a porous support, characterized in that the TS coefficient defined by the following formula (I), obtained with the use of an optical isomer separation column for simulated moving bed chromatography wherein the packing is charged in a column pipe according to slurry filling technique, is in the range of 0.55 to 1.20. TS coefficient = [Vc - [t(TS) - t(blank)] Chi FR] / [t(TS) - t(blank)] Chi FR (I) wherein Vc represents column volume (cm<3>); FR represents flow rate (ml/min); t(TS) represents elution time (min) of tetrakis(trimethylsilyl)silane (=TS); and t(blank) represents TS elution time exhibited in column non-connection condition.