发明名称 |
TECHNETIUM-LABELED ROTENONE DERIVATIVES, AND METHODS OF USE THEREOF |
摘要 |
One aspect of the present invention relates to Tc-99m-labeled rotenone derivatives. These derivatives are useful, for example, as myocardial blood flow imaging agents. Reported herein are the synthesis, radiolabeling, and testing of Tc-99m-labeled rotenone complexes as single photon emitting probes for improved delineation of myocardial perfusion. The Tc-99m-rotenone derivatives have unique properties. The instant invention also relates to technetium-99m-labeled rotenone derivatives which exhibit high uptake and retention in the myocardium in proportion to flow. Another aspect of the present invention relates to kits compring a Tc-99m-labeled rotenone derivative.
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申请公布号 |
WO03086476(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
WO2003US08883 |
申请日期 |
2003.03.21 |
申请人 |
BIOSTREAM, INC.;BABICH, JOHN, W.;MARESCA, KEVIN, P. |
发明人 |
BABICH, JOHN, W.;MARESCA, KEVIN, P. |
分类号 |
A61K51/04;A61K51/08;(IPC1-7):A61K51/00 |
主分类号 |
A61K51/04 |
代理机构 |
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