PHARMACEUTICAL COMPOSITIONS COMPRISING A 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITOR AND A DIURETIC AGENT

摘要

We provide a composition comprising a first agent which is an antagonist of 11beta-HSD1, together with a second agent comprising a diuretic. The second agent may comprise a molecule which is capable of modulating an interaction between the first agent and 11beta-HSD2. Such a composition may be used for improving cognitive ability of an individual, specifically verbal fluency or verbal memory or logical memory (or any combination thereof), or for treatment of Mild Cognitive Impairment (MCI).