ANTIVIRAL THERAPY ON THE BASIS OF RNA INTERFERENCE

摘要

The invention concerns a new gene therapy for treatment of animals and human s which suffer from an infection with a chronic virus such as HIV or HCV. It c an also be used prophylacticly to prevent chronic infection. The therapy makes use of a nucleotide construct stably integrated in the genome of the target cells of the virus, which is able to produce a single transcript or multiple transcripts capable of forming a double-stranded RNA which inhibits replication of the virus in situ.