| 发明名称 |
Recombinant virus immunotherapy |
| 摘要 |
Attenuated recombinant viruses containing DNA coding for a cytokine and/or a tumor associated antigen, as well as methods and compositions employing the viruses, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The DNA can code for at least on of: human tumor necrosis factor; nuclear phosphoprotein p53, wildtype or mutant; human melanoma-associated antigen; IL-2; IFNg; IL-4; GNCSF; IL-12; B7; erb-B-2 and carcinoembryonic antigen. The recombinant viruses and gene products therefrom are useful for cancer therapy.
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| 申请公布号 |
US2003198623(A1) |
申请公布日期 |
2003.10.23 |
| 申请号 |
US20020267384 |
申请日期 |
2002.10.09 |
| 申请人 |
PAOLETTI ENZO;TARTAGLIA JAMES;COX WILLIAM I. |
发明人 |
PAOLETTI ENZO;TARTAGLIA JAMES;COX WILLIAM I. |
| 分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K38/16;A61K38/17;A61K38/21;A61K39/00;A61K39/12;A61K39/145;A61K39/17;A61K39/205;A61K39/275;A61K39/285;A61K48/00;A61P35/00;A61P37/04;C07H21/04;C07K14/015;C07K14/02;C07K14/03;C07K14/035;C07K14/045;C07K14/05;C07K14/06;C07K14/065;C07K14/07;C07K14/11;C07K14/12;C07K14/125;C07K14/145;C07K14/15;C07K14/155;C07K14/16;C07K14/165;C07K14/175;C07K14/18;C07K14/33;C07K14/47;C07K14/52;C07K14/525;C07K14/535;C07K14/54;C07K14/55;C07K14/57;C07K14/705;C07K14/82;C12N7/00;C12N15/00;C12N15/19;C12N15/86;C12N15/863;C12P21/04;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
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