LYOPHILIZED AND LIQUID PREPARATIONS COMPRISING A POLYSACCHARIDE DERIVATIVE OF CAMPTOTHECIN

摘要

The present invention relates to a stable liquid preparation comprising a camptothecin derivative which is prepared by binding a compound of the formu la [I]:wherein R1 is a substituted or unsubstituted lower alkyl group, X1 is a group of the formula: -NHR2 (R2 is a hydrogen atom or a lower alkyl group) o r a hydroxy group and Alk is a straight or branched chain alkylene group optionally interrupted by an oxygen atom, and a polysaccharide having carbox yl groups via an amino acid or a peptide, or a pharmaceutically acceptable salt thereof, which is adjusted to pH 5-8, or a stable pharmaceutical composition produced by lyophilizing said liquid preparation.