发明名称 |
Peptide-based vaccine for influenza |
摘要 |
<p>A human synthetic peptide-based influenza vaccine for intranasal administration comprises a mixture of flagella containing at least four epitopes of influenza virus reactive with human cells, each expressed individually in Salmonella flagellin, said influenza virus epitopes being selected from the group consisting of: (i) one B-cell hemagglutinin (HA) epitope; (ii) one T-helper hemagglutinin (HA) or nucleo-protein (NP) epitope that can bind to many HLA molecules; and (iii) at least two cytotoxic lymphocyte (CTL) nucleoprotein (NP) or matrix protein (M) epitopes that are restricted to the most prevalent HLA molecules in different human populations.</p> |
申请公布号 |
AU766883(B2) |
申请公布日期 |
2003.10.23 |
申请号 |
AU20000014066 |
申请日期 |
1999.11.28 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
RUTH ARNON;TAMAR BEN-YEDIDIA;RAPHAEL LEVI |
分类号 |
A61K;A61K39/112;A61K39/145;A61P27/16;A61P31/16;C07K7/06;C07K7/08;(IPC1-7):A61K39/145;C07K14/11 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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