| 摘要 |
<p>It is intended to provide drugs to be used in gene therapy whereby an immune response to a transferred gene product in gene therapy for a recessively transmitted genetic disease can be inhibited, and a method of treating a genetic disease such as a recessively transmitted genetic disease by using such a drug. Namely, a drug to be used in gene therapy for recessively transmitted genetic disease containing an immunosuppressant and a gene responsible for a recessively transmitted genetic disease such as recessively transmitted trophic congenital epidermolysis bullosa, junctional congenital epidermolysis bullosa, hemidesmosomal congenital epidermolysis bullosa or congenital ichthyosis is prepared. The above-described immunosuppressant is exemplified by cyclosporin and CD40L antibody. The gene responsible for a recessively transmitted genetic disease as described above is usable in the form of a virus vector or a naked DNA.</p> |
