发明名称 |
IDENTIFICATION AND CLONING OF A NOVEL HUMAN GENE, RET16, INVOLVED IN THE INTRACELLULAR SIGNALING CASCADE |
摘要 |
The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.
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申请公布号 |
WO02066494(A8) |
申请公布日期 |
2003.10.23 |
申请号 |
WO2002US05162 |
申请日期 |
2002.02.15 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;TODDERUD, C., GORDON;FINGER, JOSHUA, N.;RILLEMA, JILL |
发明人 |
TODDERUD, C., GORDON;FINGER, JOSHUA, N.;RILLEMA, JILL |
分类号 |
G01N33/50;A61K38/00;A61P1/04;A61P9/10;A61P11/00;A61P11/06;A61P17/06;A61P19/02;A61P19/04;A61P25/00;A61P29/00;A61P35/00;A61P37/06;C07K14/47;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12P21/02;C12Q1/02;C12Q1/48;C12Q1/68;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C07K/ |
主分类号 |
G01N33/50 |
代理机构 |
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地址 |
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