| 摘要 |
Composition and method for preventing or treating abnormal bone resorption i n mammals, the composition characterized as containing, a supplementary effective amount of a non-activated metabolite of vitamin D2 and/or D3 and a pharmaceutically effective amount of bisphosphonate to provide vitamin D nutrition during treatment to facilitate normal bone formation and mineralization, while minimizing the occurrence of or potential for the complications associated with vitamin D insufficiency, such as hypocalcemia and osteomalacia. The method of preventing or treating may be further characterized by concomitantly administering the components simultaneously o r alternately at dosing intervals selected from once-weekly, twice-weekly, bi- weekly, monthly, and bi-monthly.
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