Adjuvant enhanced immunotherapy

摘要

An improved method is provided for treating disease states characterized by the existence of pathogenic cell populations. In accordance with the improved method, cell-targeted ligand-immunogen or ligand-hapten complexes are administered to a diseased host to redirect the host immune response to the pathogenic cells which have an accessible binding site for the ligand. The method comprises the step of administering to the host a ligand-immunogen or ligand-hapten conjugate composition comprising a complex of the ligand and the immunogen or hapten wherein the immunogen/hapten is recognized by an endogenous antibody in the host or directly by an immune cell in the host. The improvement to the method comprises the step of using a TH1-biasing adjuvant to enhance the immune response to cell-bound ligand-immunogen or ligand-hapten conjugates.