| 发明名称 |
IMPROVED CC-1065 ANALOG SYNTHESIS |
| 摘要 |
<p>Improved synthesis of seco(-)CBI (5-hydroxy-3-amino-1-[S]-(chloromethyl)-1,2 - dihydro-3H-benz(e)indole) (I) and improved syntheses therefrom of a wide variety of CC-1065 analogs that comprise a cyclopropabenzidole (CBI) alkylating moiety, and which are collectively DC1 and its derivatives, for t he synthesis of cell-targeted therapeutic agents.</p> |
| 申请公布号 |
CA2456453(A1) |
申请公布日期 |
2003.10.23 |
| 申请号 |
CA20032456453 |
申请日期 |
2003.03.19 |
| 申请人 |
IMMUNOGEN, INC. |
发明人 |
CHARI, RAVI V. J.;ZHAO, ROBERT YONGXIN |
| 分类号 |
A61K31/404;A61P31/04;A61P35/00;C07C271/12;C07D209/60;(IPC1-7):C07D209/56;C07C223/06 |
主分类号 |
A61K31/404 |
| 代理机构 |
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代理人 |
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| 主权项 |
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