| 摘要 |
<p>Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is equal or more than 70 %, 75 % , 80 %, 85 %, 90 %, 95 %, 96 % , 97 %, 98 %, or 99 % with an amino acid sequence coded by a nucleotide sequence selected from the group consisting of nucleotide sequences identifies SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93; said mutation resulting in attenuated virulence of the bacterium. Immunogenic compositions and vaccines containing such as a mutant are also disclosed and claimed.</p> |
