The invention relates to the modification of human Factor VIII (FVIII) to result in FVIII proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo. The invention relates furthermore to T-cell epitope peptides derived from said non-modified protein by means of which it is possible to create modified FVIII variants with reduced immunogenicity.
申请公布号
WO03087161(A1)
申请公布日期
2003.10.23
申请号
WO2003EP04063
申请日期
2003.04.17
申请人
MERCK PATENT GMBH;JONES, TIM;BAKER, MATTHEW;CARR, FRANCIS, J.