发明名称 |
Methods of treating sickle cell disease |
摘要 |
The present invention relates to methods of treating sickle cell disease comprising reducing, in a subject in need of such treatment, the adherence between sickle RBCs and leukocytes. It is based, at least in part, on the discovery that leukocytes play a direct role in the initiation of venular occlusion. The present invention further provides for methods for identifying agents which decrease SS-RBC/leukocyte adherence and for animal models which may be used to further elucidate the mechanism of vaso-occlusion in sickle cell crises.
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申请公布号 |
US2003198639(A1) |
申请公布日期 |
2003.10.23 |
申请号 |
US20020123373 |
申请日期 |
2002.04.16 |
申请人 |
FRENETTE PAUL S.;COLLER BARRY S.;TURHAN ASLIHAN |
发明人 |
FRENETTE PAUL S.;COLLER BARRY S.;TURHAN ASLIHAN |
分类号 |
C07K16/24;C07K16/28;(IPC1-7):A61K39/395 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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