| 摘要 |
The present invention provides a transplant rejection suppressor usable as pharmaceuticals (oral preparations, eye drops, injections, infusions and the like) effective for suppressive treatment of human organ transplant rejection by detecting an oxidized and/or reduced glutathione content in macrophage cells using a body fluid/cell sample separated and collected from human beings to classify macrophages into oxidative macrophages and reductive macrophages different from each other in function, and artificially deviating the presence ratio thereof to oxidative macrophages with a specific low-molecular compound or artificially removing reductive macrophages, and further provides a use of the active ingredient for this purpose or a method for suppressing transplant rejection. <??>Moreover, the invention can suppress the transplant rejection using the transplant rejection suppressor and also can provide foods, drinks (health foods and the like), nutriments and the like useful for suppressing the transplant rejection. <??>Especially, the invention can effectively inhibit (suppress) the rejection of the transplantation for the purpose of treatment, improvement and/or prevention of diseases accompanied by rejection in transplantation of human organs such as human liver, heart, lung, kidney, skin, cornea and corneal epithelium and stem cell transplantation of tissues, especially the organ transplantation.
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